Tirzepatide

Tirzepatide is a dual GIP and GLP-1 receptor agonist designed to enhance insulin sensitivity, improve blood sugar regulation, and support significant weight reduction by mimicking natural gut hormones that control appetite and metabolism.

Clinical studies show that tirzepatide can lead to substantial improvements in body composition, including reduced visceral fat and better cardiovascular markers, making it a promising option for individuals struggling with obesity or metabolic dysfunction.

Research indicates that tirzepatide not only promotes weight loss but also helps regulate hunger hormones, reduce cravings, and stabilize energy levels, offering a comprehensive approach to long-term metabolic health.

Tirzepatide has been shown to improve multiple metabolic health markers beyond weight loss, including reductions in fasting blood glucose, HbA1c, and triglyceride levels. These effects indicate that the medication can support overall metabolic function and cardiovascular health, making it beneficial for people with obesity, prediabetes, or type 2 diabetes in addition to promoting fat loss.

Semaglutide

Semaglutide is a glucagon‑like peptide‑1 (GLP‑1) receptor agonist originally developed for type 2 diabetes (as brand names such as Ozempic) and now also approved for chronic weight management (as Wegovy). It mimics the endogenous GLP‑1 hormone to enhance insulin secretion when glucose is high, suppress inappropriate glucagon release, delay gastric emptying, reduce appetite, and thereby help regulate blood sugar and body weight.

Clinical trials have demonstrated significant outcomes with semaglutide: for example, in one major trial participants lost an average of nearly 15% of their body weight over 68 weeks — a level of weight reduction comparable in some cases to more invasive interventions. In addition, semaglutide has shown improvement in metabolic markers and reductions in cardiovascular risk among people with diabetes.

Semaglutide has notable side effects and contraindications: the most common adverse reactions are gastrointestinal (nausea, vomiting, diarrhea, constipation) as the body adapts to slowed gastric emptying and appetite suppression. It is contraindicated in people with a personal or family history of medullary thyroid carcinoma (MTC) or with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Close medical supervision is required when using GLP‑1 therapies to monitor safety and individual response.

NAD

NAD⁺ is a coenzyme present in every living cell and plays a central role in converting nutrients into cellular energy, supporting mitochondrial function, and participating in DNA repair and gene‑regulation processes via enzymes such as sirtuins and PARPs.

NAD⁺ levels decline substantially with age—studies indicate roughly a 50% reduction between the ages of 40–60—which is associated with fatigue, diminished metabolic efficiency, reduced cellular repair capacity, and other signs of aging.

Supplementation with NAD⁺ (or its precursors) is promoted for benefits such as enhanced cellular energy, improved cognitive clarity, better metabolic and mitochondrial health, and support for age‑related functional decline. However, bioavailability, quality of formulation, and individual metabolism all affect outcomes.

Sermorelin

Sermorelin is a synthetic analog of the 1–29 amino acid fragment of human growth hormone–releasing hormone (GHRH), designed to stimulate the pituitary gland to secrete growth hormone in a more natural “pulsatile” pattern rather than simply replacing growth hormone directly.

Key benefits observed in clinical or off‑label use include improved body composition (lean mass gain and fat reduction), enhanced sleep quality, increased energy and vitality, supporting recovery and metabolic health.

Use of sermorelin is generally under medical supervision because it involves hormone‑axis stimulation. Contraindications or caution apply for individuals with active or recent malignancies, pituitary tumors, uncontrolled endocrine disorders, and it is often compounded rather than FDA‑approved for many of these uses.

Glutathione

Glutathione is a naturally occurring tripeptide (composed of glutamine, cysteine, and glycine) that serves as a major intracellular antioxidant—protecting cells from oxidative stress, supporting detoxification in the liver, maintaining immune system health, and helping regenerate other antioxidants like vitamin C and E.

Glutathione levels in the body decline with age, stress, and exposure to environmental toxins, which may contribute to increased oxidative damage, reduced metabolic resilience, and diminished cellular repair capacity. Supplementing or restoring glutathione levels is therefore often presented as a strategy to support detoxification, skin health, cellular energy and metabolic balance.

The preparation and use of glutathione require careful handling: when provided as a lyophilized powder it must be properly reconstituted, stored refrigerated after mixing, and used under conditions that maintain stability. Some compounded preparations specify administration via injection (IM or IV) and caution that product quality, sterility, and medical oversight are essential.